Although it is quite possible to harm yourself when using Ayahuasca, there are only very few, if any, severe injuries or deaths associated with it. Ayahuasca contains a potentially hazardous component: A MAO inhibitor - a substance that inhibits a key enzyme in the body which is responsible for several processes in the body and brain. To prevent severe negative reactions to Ayahuasca it is recommended to find out how MAO inhibitors interact with prescribed medications and certain foods before using it.
MAO inhibitors must not be combined with any other drugs - the consequences can be much worse than unpleasant and in the worst case fatal.
Ayahuasca is a very strong psychedelic and can cause psychotic or neurotic episodes and changes in personality.
Ayahuasca can and most likely will have utterly negative side effects if taken in combination with anti-depressants and Serotonin re-uptake inhibitors.