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How To Dose Mescaline Cacti Properly

How To Dose Mescaline Cacti Properly

Mescaline is a psychedelic substance that can be found in a variety of sacred cacti, including Peyote (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi), and the Peruvian Torch cactus (Echinopsis peruviana). It is important to know that finding the right dosage of mescaline for a trip isn’t always straightforward, since there are numerous variables to consider. Here is all the information you need to know about mescaline cacti and how to dose them properly.

The effects of mescaline are comparable to those of LSD and mushrooms. It is not uncommon for psychonauts to consider their experiences and visions during a mescaline trip as deeply profound and life-altering.


Mescaline is normally taken in the form of a powder, pill, or liquid. An effective dosage for a psychedelic trip can vary. In most cases, users take between 200–500 milligrams of mescaline at a time if they want to experience a moderate to strong trip. Once ingested, the effects of mescaline will normally set in after 1–2 hours.

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Given that dosage is contingent on many factors, we cannot offer a silver bullet value for everyone. Individuals can and will react differently to the same dosage. What is just enough for one person may be too much for another.

Likewise, mescaline dosages that you find listed on the web are often based on mid-sized plants with average potency. However, the mescaline content and therefore potency of mescaline cacti can vary greatly. This can depend on the age of the cactus, where the plant is coming from, and even the season it was harvested. For instance, cacti harvested in winter can be more potent than those harvested in summer. Keep these things in mind and always start with low dosages at first. Gradually experiment from there, so you can find what works best for you.


Peyote (Lophophora williamsii)

Peyote or El Mescalito, the “living God”, is probably the most widely known of the psychedelic mescaline cacti. The small cactus that rarely rises more than 3–4cm above the surface has a long history of use among the natives in Mexico and parts of the Southwestern US. According to archaeologists, peyote has been known and used for at least 5,700 years.


Keep the above cautions in mind when looking to find your ideal dosage for the peyote cactus. On average, 27g of dried peyote or 125g of fresh cactus will make for about 300mg of mescaline.

In case you are not weighing a dry or a fresh plant, but instead measure by “buttons” (with each button measuring 2.5cm in diameter), you will need 8–10 buttons for the same dose, either dried or fresh.


Besides the Peyote cactus, columnar mescaline cacti such as San Pedro (Echinopsis pachanoi), Peruvian Torch (Echinopsis peruviana), and Bolivian Torch (Echinopsis lageniformis), along with some lesser-known mescaline cacti such as the Trichocereus macrogonus, have long played important roles for healing and spiritual purposes in Middle and South America. Columnar cacti all have one very specific growing trait in common: they grow tall and straight, like a column. Hence the name.



Traditionally, columnar cacti are measured by length for determining the right dose for a mescaline trip. On the other hand, recommendations such as “a piece the length of your forearm, from elbow to knuckle” do not take into account their diameter, which makes this way of measuring rather inaccurate for dosing. After all, it is the volume of the cactus that determines the total mescaline content, and not just the length. That being said, a cactus piece about 25–30cm long with a thickness of 5–8cm normally makes for an average dose.

If you are weighing cacti instead of measuring, 100g of fresh columnar cactus contains, on average, 120mg of mescaline, which means you’d require anywhere from 170–420g of cactus to get about 200–500mg of mescaline. Know that the skins of these cacti hold most of the mescaline, so one should remove as little of it as possible.

How To Consume A Mescaline Cactus

Mescaline has roots in Native American tradition and is used today as a potent psychedelic with serious spiritual potential.


What we mentioned earlier about the varied strength of peyote and other hallucinogenic cacti is true for columnar cacti as well, like the San Pedro cactus. A recent precise chromatographic measurement of six different samples of San Pedro found that their mescaline content ranged from 1.09–23.75μg per mg of dried material. In other words, their potency can vary substantially!

Keep these considerations in mind when you want to go on a psychedelic journey with mescaline cacti. Remember, it’s always better to start with a lower dosage first, which you can always gradually increase later.

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