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Kanna Chemistry

The chemical constituents of Kanna are thought to induce both mood-elevating and anti-anxiety effects. There are four psychoactive alkaloids that have been identified within kanna, these are:


MesembrineThis is the central alkaloid contained in kanna. There is a debate over wether mesembrine is a actually a selective serotonin reuptake inhibitor (SSRI), or just mimics its function. Mesembrine is a mild inhibitor of phosphodiesterase 4 (PDE4).



MesembrenoneMesembrenone acts as a more balanced version of Mesembrine, but is found in smaller quantities. It is a weaker SSRI, but a stronger PDE 4 inhibitor.




MesembrenolNot much is known about mesembrenol, other than it is psychoactive.




TortuosamineThis is another alkaloid that was discovered in Kanna. Unfortunately, alsp very little is known about it - other than it is psychoactive.


The total alkaloid content of Kanna is roughly 1.5%



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