Mescaline itself acts psychedelic at oral doses of 5 milligrams per kilogram of body weight. For a 70 pound man, this would equal to a dose of 350 milligrams of pure mescaline. Although mescaline is toxic at extremely high doses, there is to date no known fatality caused by the cactus drug. In experiments of psychonauts, even very high doses of up to 1.5 grams were survived. Yet taking such large amounts is definitely inadvisable and dangerous. In our case we are referring to a dose of mescaline cacti, not to the pure active compound. Let's have a look at the well-known first.
Peyote is taken in doses of 4 to 35 buttons. It varies and depends on the potency, the size of the buttons and also the intended purpose. In general it can be said, that about 15 to 20 grams of dry matter of Peyote correspond to a dose, that is somewhere from 200 to 600 milligrams of mescaline. This can be a psychedelic experience.
San Pedro is traditionally dosed by size. But even here the guidelines also apply, so about 30 to 35 grams of dry matter correspond to a psychedelic experience, depending on the potency. Traditionally, however, a piece of approximately 25cm length and 5 to 10cm in diameter per person and experience is used. But beware! There are two kinds of San Pedro cactus! Besides Echinopsis (Trichocereus) pachanoi, this is Echinopsis peruviana (Trichocereus peruvianus), which is at least twice as potent, if not even more noticeably!
Although dosing information for the isopod cactus Pelecyphora aseliformis is missing, however, it is known, that this cactus, cleaned from thorns, peeled and eaten fresh and the Peyote should be quite similar, but considerably weaker. Pelecyphora aseliformis contains small amounts of mescaline. Let's have a look at those cacti that have particularly high mescaline contents.
|Strain substance (dry)||Habitat||Active|
|Echinopsis lageniformis||Bolivia, Peru||up to about 1%|
|Echinopsis pachanoi||Peru||about 2%|
|Echinopsis peruviana||Peru||about 6-20% (!)|
|Echinopsis terscheckii||Argentina, Peru||up to about 1%|
|Lophophora, all kinds||Mexico||up to about 4%|
|Opuntia cylindrica||Chili||up to about 0.9%|
Note: Fresh mescaline cacti material contains significantly less than dried.
Let us remember, that at a mescaline dose of 200 to 600 milligrams per session per person equals to a medium to strong psychedelic experience. Heeding this rule of thumb and then almost knowing how potent the available material is, then nothing stands in the way for a correct dosage. Otherwise: gradually increase dose carefully. Less is more!