Although passionflower is mild MAOI, dietary precautions should be followed. For more information about restricted items, please refer to the The Ayahuasca MAOI Diet.
Do not take passionflower if you are pregnant or breastfeeding. Passionflower is generally considered to be safe and nontoxic in recommended doses. Because of its calming effect, passionflower can increase the sedative effects of prescription drugs, so avoid combinations with barbiturates, benzodiazepines, drugs for insomnia, or tricyclic antidepressants.