Syrian rue, scientific name Peganum Harmala, is a perennial shrub native to the Mediterranean and various regions of Asia. It can now also be found growing wild on the American continent. Part of the Nitrariaceae plant family, Syrian rue can grow up to 1m, but in the wild rarely gets above 0.3m in height. It has narrow leaves that are usually 5 cm long when fully grown and produces many single white flowers.
The seeds of Syrian rue are of most interest, as they contain the harmala alkaloids harmine and harmaline – highly psychoactive alkaloids that are sometimes used to potentiate other plants, although it is reported that harmala alkaloids are psychoactive by themselves. They also act as reversible MAO inhibitors (RIMAs), for which reason Peganum Harmala is commonly used to activate oral DMT.