The main active compound found within Leonotis leonurus is known as leonurine. It is a mildly psychoactive alkaloid, also found within a few other members of the same family of plants (but often to a lesser degree).
Research suggests that the chemical compounds of Leonotis leonurus may possess antinociceptive, antiinflammatory, and hypoglycemic properties. Source: Ojewole JA (May 2005). "Antinociceptive, antiinflammatory and antidiabetic effects of Leonotis leonurus (L.) R. BR. [Lamiaceae] leaf aqueous extract in mice and rats“. Methods and Findings in Experimental and Clinical Pharmacology 27 (4): 257–64