5 min

The Benefits Of Different CBD:THC Ratios

5 min
CBDshop Research

Differing CBD:THC ratios can have a massive effect on the way cannabis interacts with the body. Research into the phenomenon is still ongoing, but here is what we know so far.

As more and more people are considering cannabis as a support for their well-being, patients, users, researchers and physicians are focusing on cannabinoids’ ratios, instead of just considering their dosage in milligrammes. Different combinations of THC and CBD might help diseases for which there has been limited therapeutic results to date.

With cannabis, there is no single ratio, or strain or concentrate that’s right for everyone. Each single person’s sensitivity to THC is a key factor in determining the appropriate ratio and dosage for effective usage.



The two main cannabinoids can exert significantly different effects, both alone or combined in different proportions. This difference is becoming a central argument in understanding any medical benefit of cannabis, and it’s also an important issue to consider if you just want to “fine tune” your high.

The mechanisms by which cannabinoids exert their therapeutic action are still being investigated. The endogenous or pharmaceutical stimulation of our endocannabinoid system causes diverse biological responses, which can be anything from a nice high, dizzy head, pain relief, reduced inflammation, or the start of a complex healing process.

An important difference between CBD and THC stays in the biochemical mechanisms by which these slightly different molecules actually bind with animals’ cannabinoids receptors. THC binds well with a specific neuronal receptor named CB1, while CBD binds mostly with the receptor CB2. CBD reduces or “antagonises,” some of the effects of THC like anxiety, paranoia, tachycardia, and possibly the high itself, by partially blocking CB1 receptors.

THC is believed to be responsible for most of cannabis' sleep-inducing effects. On the other hand, studies suggest CBD acts to promote wakefulness. Research on the benefits of tetrahydrocannabinol and cannabidiol in isolation is pretty clear: THC demonstrates analgesic, anti-emetic, and anti-inflammatory properties. CBD showed similar actions, plus anti-psychotic, anti-seizure, and anti-anxiety properties.

Clinical research on the simultaneous use of THC and CBD is just at its first stages. However, people reported better effects and less anxiety with hybrids containing a balanced proportion of CBD and THC than using strains with high THC alone. It also seems that CBD enhances THC’s painkilling and anticancer properties, while both CBD and THC stimulate neurogenesis, the creation of new cells in the nervous system.

Top 7 Cannabis Strains With A Unique THC:CBD Ratio

We give you a run-down on several strains and their unique THC:CBD ratios. Find out which strain may work best for your individual needs...

A common therapeutic strategy seems to be administering consistent and measurable doses of CBD plus as much THC as a person is comfortable with. Some conditions seem to respond well to a small dose of a CBD with little THC, while others benefit more from a balanced ratio around 1:1. Different CBD:THC ratios can also be used at different times of the day. What follows is a rough description of the effects for each one of the significant CBD:THC ratios that people are today looking for, together with a selection of the corresponding cannabis genetics.



People using THC-only strains in big amounts will experience the most psychoactive events. These can be legitimately desired or they can be just unwanted side effects. High THC cannabis derivatives can cause euphoria, uplifting mood, laughs and dizziness. Their main adverse effects are tachycardia, anxiety and paranoia.

As cannabinoids naturally occur together in different percentages, there are no strains with a 0% of CBD. Some hybrids are close to this ratio, though. For example: Gorilla Glue by Zamnesia has a THC content of 25%, while Girl Scout Cookies is loaded with 22% of THC. Critical Kush by Barney's Farm pushes the limit with a lab-tested THC content of 25%.



The psychoactive effects are still well present with a CBD:THC ratio of 1:2, even if the action of CBD begins to be perceivable in a more relaxed mood. The risk of tachycardia, anxiety and paranoia is reduced.

A powerful sativa-dominant strain with a strong THC content and high amount of CBD is the feminized Amnesia Haze by Royal Queen Seeds, which is commonly used as a medical strain.

A variety with less THC (a respectable 12-16%) and a counterbalancing moderate CBD level is Blue Widow by Dinafem, a crossing between the notorious White Widow and the Blueberry. Another option with a potent nature is OG Kush by Zamnesia Seeds. Its THC content can reach over 20%, targeting a number of different ailments such as chronic pain, stress, anxiety, insomnia, migraines and muscles spasms.



Research so far seems to have found that 1:1 THC:CBD ratio provides the most therapeutic relief across wide categories of ailments, with just minor side effects. This proportion between cannabinoids is having the best effect on sleep, pain and muscle spasms reduction, and it is under research for the treatment of autism, cancer, fibromyalgia, and skin diseases. The relaxation comes with very light high effect and little euphoria.

Cannatonic by Resin Seeds is a famous strain with an almost 1:1 ratio. It is a cross of MK Ultra and the G13 Haze. Another interesting strain is Critical Mass CBD, which is the medical version by Dinafem of the popular Critical Mass. This CBD version has the optimized 1:1 ratio between CBD and THC. The autoflowering world also has this kind of proportion between cannabinoids: Sweet Tooth Auto comes from the original regular Barney's Farm strain, and it reaches up to 15-16% THC with an equivalent CBD content.



Increasing the CBD intake using strains with around 2:1 ratio progressively eliminates feelings of euphoria, dizziness and other eventual side effects of THC. This makes cannabis treatments suitable for even the most sensitive patients. A perfect example of this kind of strains is Kama Kush CBD by Kannabia. This is a medicinal plant that delivers a calming effect with 12% of CBD and only up to 6% of THC. Another one is CBD Critical Cure, an outcome of a joint venture between Barney's Farm and the CBD Crew which is grown mainly for medical purposes. Its CBD level of 8% doesn’t allow THC to cause a heavy stone or other undesired side effects. Within the automatic families, Cheese Autoflowering from Dinafem contains a higher CBD level than the normal notorious Cheese, making it more suitable medical applications.



Zero THC means none of the so-called mind-altering effects of cannabis are experienced. No kind of impairment is linked to the intake of cannabis lacking THC.

A full-CBD strain can lift mood and bring many other benefits to our mind, health and well-being. Cannabidiol is getting widely recognised as an effective anti-psychotic and relaxing compound, both on a central and peripheral level, with no side effects. Initial lab and clinical research tests are indicating enormous potential applications for CBD in medicine - though there is still a way to go.

6 Cannabis Strains With 1% THC Or Less

THC is the psychoactive cannabinoid, that makes marijuana users high. If marijuana contains very little of THC, can it still be an enjoyable experience?

There are probably no strains out there with 0% THC, yet a few strains do get close to this ratio. CBD Therapy by CBD Crew is a cannabis variety with 8-10% CBD and just 0,5% THC, equivalent to a 20:1 CBD:THC ratio. These figures are verified by both EU and USA based labs, and they make CBD Therapy one of the most CBD-rich, low THC, strains available. Candida (CD-1) by Medical Marijuana Genetics, which is another rare strain with THC under 1% and CBD around 20%. This indica/sativa hybrid likely provides the highest CBD and lowest THC content of any cannabis strain today available.



CBD broadens the potential range of conditions treatable with cannabis. CBD-rich strains may help with diverse neurological and psychological issues, such as anxiety, depression, schizophrenia, epilepsy, post-traumatic stress disorders, Parkinson’s disease. Cannabidiol can remove the plaque that affects brain cells hit by Alzheimer’s disease.

CBD also showed, both in lab and clinical trials, to be able to target autoimmune conditions like psoriasis, colitis and Chron’s disease, arthritis, multiple sclerosis, diabetes, and various kind of chronic pain and inflammations. Undergoing studies are showing promising results against cancer, cardiovascular diseases, and antibiotic-resistant infections.

The last two strains we mentioned, Candida and CBD Therapy, are particularly important for future research on CBD, as they allow physicians and patients to tailor THC-free therapies for patients in need of huge amounts of CBD to treat their conditions. More standardised lab testing on each medical strain is needed to provide a scientific basis for understanding the clinical effects of different amounts and ratios of cannabinoids. Patients obtain a wide spectrum of compounds from the whole cannabis plant. Thus terpene profiles should also be considered as they may alter the effects of THC and CBD.


Written by: Zamnesia
Zamnesia has spent years honing its products, ranges, and knowledge of all things psychedelic. Driven by the spirit of Zammy, Zamnesia strives to bring you accurate, factual, and informative content.

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