Liposomal CBD Oil (Zamnesia) 4%
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How Can Liposomes Improve CBD Absorption?

4 min
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Liposomes are the next big thing in CBD technology. Comprised of phospholipids, liposomes improve absorption of CBD into the body by transporting it through the intestinal membrane, safely into targeted tissues. See how liposomes will change the way you dose your daily CBD.

Sometimes the biggest advancements in cannabis science come in the smallest packages. As is the case with liposomes, there is now a way to maximise CBD absorption into the body with the help of tiny lipid “bubbles.”

It appears that CBD is finding its footing in mainstream science after decades of cannabis prohibition and oppressive stigma against cannabinoids-as-medicine. Now that there is greater awareness of how cannabinoids can benefit human health, we are finally getting closer to a worldwide easing of tensions on the issue.

As a result, manufacturers are developing more advanced cannabis products to keep up with surging demand. As some companies charge ahead of the competition with potent CBD supplements, liposomes are increasingly being employed to optimise active ingredient absorption.

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Liposomes are secure vesicles made of one or more phospholipid bilayers. For the most part, liposomes are prepared in a lab setting by disrupting phospholipids into forming a spherical and protective bubble. Some consider liposomes to be the future of the nutraceutical industry because they safely administer active ingredients through the GI tract into designated targets throughout the body.


Phospholipids contain a hydrophilic (water-loving) head and a hydrophobic (water-hating) tail. When submerged into water, the tails turn inward and the heads turn out in attraction to the water. This causes them to form a bilayer, which can safely encapsulate ingredients and protect them from harm.


History Of Liposomes

First discovered by Alec D. Bangham and R.W. Horne in 1961, liposomes would eventually gain traction upon being the subject of a scientific review published in 1965. Liposomes are perhaps the most popular mechanism used for targeted drug delivery in the pharmaceutical industry. It was only in recent years that the nutraceutical industry adopted liposomes as a mode of transport to increase bioavailability of nutrients.


A primary reason for liposomes’ popularity is their safety. Again, liposomes are comprised of phospholipids and are therefore non-toxic, non-immunogenic and both biodegradable and biocompatible. There are virtually no adverse side effects to liposomes or their consumption in drugs or supplements.

Liposomes are unique to other delivery methods in that they can transport ingredients past the intestinal membrane into specific tissues. When prepared correctly, they also ensure full protection of the contents inside. This is why bioavailability of nutrients is so high when liposomes are used in dietary supplements.

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Advantages Of CBD With Liposomes

CBD and liposomes are a winning combination by all standards. Effective in its own right, CBD is repeatedly studied as a potential treatment for physical and psychological conditions like chronic pain, PTSD, Dravet syndrome and many others. When encapsulated by liposomes, CBD is given the opportunity to provide its full course of effects on targeted tissues. By protecting CBD from being compromised, liposomes can improve CBD absorption.

CBD is a non-psychoactive compound, so ingesting it in its full form will not be overwhelming to the consumer. On the contrary, by maximising intake of CBD, it has the potential to really do some good. This is true of both oral and topical formulations - two methods of liposomal delivery that are rapidly gaining popularity. When used in skin creams and salves, liposomes allow CBD to penetrate deeper into the epidermis to thoroughly cleanse the skin. When ingested in a supplement, CBD and liposomes allow for exact and consistent dosing.

Especially for those looking to use cannabinoids for medical purposes, liposomes allow users to obtain greater percentages of wholesome CBD than they could in the past. CBD already displays accepted anxiolytic and anti-inflammatory outcomes and is consistently mentioned as a powerful mediator of the psychoactive cannabinoid THC and other natural ingredients.


Liposomes And Absorption: The Facts

A 2017 review found that “nanoparticulate” delivery systems like liposomes improve the bioavailability of nutrients by protecting the drug in the GI tract and mucous membrane, as well as by increasing cellular contact. The authors continued to assert liposomes’ added potential due to their phospholipid bilayer structure. This unique form allows them to “adhere to biomembranes, form mixed-micelle structures with bile salts to increase the solubility of poorly soluble drugs...”

Concerning CBD’s efficacy when administered in high percentages, consider the following 2003 study on “Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model.” In this case, a group of blind mice were administered CBD to determine its efficacy in treating rheumatic diseases. As a response to issues associated with oral intake, the researchers employed an ethosomal delivery method of CBD to the mice. Throughout the 72 hour experiment, the mice were tested to determine changing CBD levels in the skin.

The study found that not only was there a “significant accumulation” of CBD in the skin and muscle, there was also a significant reduction in inflammation. In conclusion, the authors suggest the legitimate possibility of CBD as an anti-inflammatory treatment when delivered using secure vehicles like ethosomes. Although ethosomes and liposomes are not the exact same, they suggest similar penetrative potential of active ingredient CBD into the body.

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With liposomes, the protective vesicle that delivers CBD to where it needs to go, liposomal CBD oils can be several times stronger than traditional oils of the same concentration. Although the liposomal formula isn’t suitable for everyone, for those who can enjoy its benefits, Zamnesia has a comprehensive range of products to suit your needs.

  • Liposomal CBD Oil (Zamnesia) 2.5% & 4%

A crucial attribute of liposomal CBD oil is the improvement in concentration afforded by the inclusion of protective liposomes. Due to the improved efficacy of CBD distribution, both the 2.5% and 4% oils by Zamnesia can be up to four times stronger. This effectively makes them comparable to 10% and 16% traditional oils. Ideal for those who need a high dose of CBD or use the cannabinoid to medicate, liposomal CBD oil has improved bioavailability and a faster onset of effects.

Liposomes make benefitting from CBD’s broad range of therapeutic effects easier than ever. Produced to the same high standard as traditional CBD oils, you can rely on the inclusion of liposomes to deliver a fast and sustained dose of CBD.

Liposomal CBD Oil (Zamnesia) 4%View Product

  • Liposomal Vitamin C with CBD (Cibdol) 150ml

Not only can liposomes improve the uptake of CBD, but many vital compounds can be incorporated into the protective barrier they provide. By shielding essential molecules from the harmful acids found within the digestive tract, liposomes have enabled Cibdol to combine CBD and vitamin C for a formula that delivers numerous benefits. Vitamin C is recommended as a daily supplement with the ability to prevent the common cold, strengthen the immune system, and act as a potent antioxidant.

In collaboration with CBD, vitamin C and liposomes are the perfect match-up. Ideal for daily consumption, the all-in-one supplement should be stored in the fridge to maintain the integrity of its ingredients.

Liposomal Vitamin C With CBD (Cibdol)View Product

  • Liposomal Multivitamin + CBD (Zamnesia)

If CBD and vitamin C make a powerful combo, then imagine the benefits of partnering cannabidiol with a selection of health-boosting multivitamins. By incorporating sixteen essential vitamins and minerals, the unique formula is exemplary for individuals who want to function at their best. Vitamins cannot be produced naturally by the human body, and instead need to be absorbed through our diet. Sometimes, eating the right balance of foods isn’t always possible, and that's why supplements are perfect for allowing us to top-up our vitamin levels.

Now you needn’t worry about remembering to take a variety of supplements in addition to CBD oil. The liposomal formula from Zamnesia brings together all the elements of a daily supplement routine and improves their uptake using liposomes.

Liposomal Multivitamin + CBD (Zamnesia)View Product


Written by: Zamnesia
Zamnesia has spent years honing its products, ranges, and knowledge of all things psychedelic. Driven by the spirit of Zammy, Zamnesia strives to bring you accurate, factual, and informative content.

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