Liposomal CBD Oil (Zamnesia) 4%
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How Can Liposomes Improve CBD Absorption?

3 min

Liposomes are the next big thing in CBD technology. Comprised of phospholipids, liposomes improve absorption of CBD into the body by transporting it through the intestinal membrane, safely into targeted tissues. See how liposomes will change the way you dose your daily CBD.

Sometimes the biggest advancements in cannabis science come in the smallest packages. As is the case with liposomes, there is now a way to maximise CBD absorption into the body with the help of tiny lipid “bubbles.”

As a result, manufacturers are developing more advanced cannabis products to keep up with surging demand and stay ahead of the curve. Liposomal formulas are a prime example of the sophisticated technology being implemented in the CBD market.

Let’s check out how liposomes are being used, and why.

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Liposomes are secure vesicles made of one or more phospholipid bilayers. For the most part, liposomes are prepared in a lab setting by disrupting phospholipids into forming a spherical and protective bubble. Some consider liposomes to be the future of the nutraceutical industry because they safely administer active ingredients through the GI tract into designated targets throughout the body.


Phospholipids contain a hydrophilic (water-loving) head and a hydrophobic (water-hating) tail. When submerged into water, the tails turn inward and the heads turn out in attraction to the water. This causes them to form a bilayer, which can safely encapsulate ingredients and protect them from harm.



First discovered by Alec D. Bangham and R.W. Horne in 1961, liposomes would eventually gain traction upon being the subject of a scientific review published in 1965. Liposomes are perhaps the most popular mechanism used for targeted drug delivery in the pharmaceutical industry. It was only in recent years that the nutraceutical industry adopted liposomes as a mode of transport to increase bioavailability of nutrients.


A primary reason for liposomes’ popularity is their safety. Again, liposomes are comprised of phospholipids and are therefore non-toxic, non-immunogenic and both biodegradable and biocompatible. There are virtually no adverse side effects to liposomes or their consumption in drugs or supplements.

Liposomes are unique to other delivery methods in that they can transport ingredients past the intestinal membrane into specific tissues. When prepared correctly, they also ensure full protection of the contents inside. This is why bioavailability of nutrients is so high when liposomes are used in dietary supplements.

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Advantages Of CBD With Liposomes

Liposomes are an excellent way to increase the bioavailability of CBD products. When taken orally, liposomes protect CBD as it travels through the throes of the digestive tract. They help the molecule to stay intact and enter the bloodstream without degrading beforehand.

Once in the bloodstream, liposomes keep CBD molecules in their protective embrace and carry them all the way to their cellular targets.

CBD is thought to produce some of its effects by interfacing with CB1 and CB2 receptors of the endocannabinoid system. It is also theorised to interact with serotonin and vanilloid receptors. Liposomes enable large quantities of CBD to reach these sites.

Liposomes are also used in topical formulas. Products such as balms, lotions, and creams introduce CBD into the skin, where it is believed to interact with the cutaneous endocannabinoid system. Liposomes help CBD reach deeper into the skin for more pronounced results.

Here, the endocannabinoid system is involved in biological processes such as proliferation, growth, and hormone production. 


Liposomes And Absorption: The Facts

A 2017 review found that “nanoparticulate” delivery systems like liposomes improve the bioavailability of nutrients by protecting the drug in the GI tract and mucous membrane, as well as by increasing cellular contact. The authors continued to assert liposomes’ added potential due to their phospholipid bilayer structure. This unique form allows them to “adhere to biomembranes, form mixed-micelle structures with bile salts to increase the solubility of poorly soluble drugs...”

There isn’t much data regarding CBD and liposomal absorption. However, animal research found ethosomes—a similar phospholipid nanotechnology—to enable CBD to effectively permeate the skin via transdermal delivery. It should be noted, however, that transdermal CBD is distinct from other topical methods in that it can penetrate the bloodstream, much like how nicotine in nicotine patches is delivered.

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With liposomes, the protective vesicle that delivers CBD to where it needs to go, liposomal CBD oils can be several times stronger than traditional oils of the same concentration. Although the liposomal formula isn’t suitable for everyone, for those who can enjoy its benefits, Zamnesia has a comprehensive range of products to suit your needs.

  • Liposomal CBD Oil (Zamnesia) 2.5% & 4%

A crucial attribute of liposomal CBD oil is the improvement in concentration afforded by the inclusion of protective liposomes. Due to the improved efficacy of CBD distribution, both the 2.5% and 4% oils by Zamnesia can be up to four times stronger. This effectively makes them comparable to 10% and 16% traditional oils. Ideal for those who need a high dose of CBD or use the cannabinoid to medicate, liposomal CBD oil has improved bioavailability and a faster onset of effects.

Liposomes make benefitting from CBD’s broad range of effects easier than ever. Produced to the same high standard as traditional CBD oils, you can rely on the inclusion of liposomes to deliver a fast and sustained dose of CBD.

  • Liposomal Vitamin C with CBD (Cibdol) 150ml

Not only can liposomes improve the uptake of CBD, but many vital compounds can be incorporated into the protective barrier they provide. By shielding essential molecules from the harmful acids found within the digestive tract, liposomes have enabled Cibdol to combine CBD and vitamin C for a formula that delivers numerous benefits. 

In collaboration with CBD, vitamin C and liposomes are the perfect match-up. Ideal for daily consumption, the all-in-one supplement should be stored in the fridge to maintain the integrity of its ingredients.

  • Liposomal Multivitamin + CBD (Zamnesia)

If CBD and vitamin C make a powerful combo, then imagine the benefits of partnering cannabidiol with a selection of health-boosting multivitamins. By incorporating sixteen essential vitamins and minerals, the unique formula is exemplary for individuals who want to function at their best. Vitamins cannot be produced naturally by the human body, and instead need to be absorbed through our diet. Sometimes, eating the right balance of foods isn’t always possible, and that's why supplements are perfect for allowing us to top-up our vitamin levels.

Now you needn’t worry about remembering to take a variety of supplements in addition to CBD oil. The liposomal formula from Zamnesia brings together all the elements of a daily supplement routine and improves their uptake using liposomes.

Adam Parsons
Adam Parsons
Professional cannabis journalist, copywriter, and author Adam Parsons is a long-time staff member of Zamnesia. Tasked with covering a wide range of topics from CBD to psychedelics and everything in between, Adam creates blog posts, guides, and explores an ever-growing range of products.
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