Kratom Not Working? This Is How To Fix It
2 min

Kratom Not Working? This Is How To Fix It

2 min
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Kratom has become a phenomena in the USA and Europe over recent years. Here are some practical tips to avoid a Kratom tolerance.


Kratom is the popular name for the dried leaves of the tropical deciduous tree Mitragyna speciosa. This member of the coffee family is native to many countries in the South East Asia, particularly Thailand and Indonesia. It has been used by indigenous peoples for centuries as a recreational psychoactive and a physically stimulating herb. Traditionally, the fresh leaves are chewed by workers in Thailand as a stimulant during hard physical work and as a mood enhancer during monotonous tasks.


There are over 25 different active compounds in Kratom including the alkaloids Raubasine, Corynantheidine, Epicatechin, Mitraphylline and Mitragynine pseudoindoxyl. The main active alkaloids being Mitragynine and 7-Hydroxymitragynine.

These alkaloids are both opioid and adrenergic receptor agonists. At lower doses, they act as a stimulant with the adrenergic effects being dominant. At higher doses, the relaxing effects dominate. Different types of Kratom have different effects due to the unique alkaloid profile of each subspecies.


Specially for regular users, a tolerance can build up. Just like any other substance the body adjusts to is use, building tolerance. The brain is a fantastic at adapting. It will downshift, making its own chemicals to compensate for the outside introduction of other compounds, so as to keep things in homeostasis or balance. This is experienced by the user as tolerance.

Tolerance can lead to increased dosing to get the desired effects compared to what could be considered a reasonably sized dose per day. Such trends, when continued, encourage desensitization and overuse.

What to do if kratom stops working? There is no magic silver bullet solution to Kratom tolerance, however, there are a few things you can do.


Avoiding the "stagnant strain syndrome" is key. This condition occurs when taking the same species for a prolonged period of time. Taking the same strain or mix of strains everyday builds resistance much faster. Therefore it is better to have several types of Kratom available and mix things up regularly, adjusting dosages and cycling strains. This way the agonist levels don't reach a stable concentration in the brain and tolerance is less likely to occur.


For those who have over indulged, the hard truth of the matter is that you will need to take a break, allowing the brain to rest and reset.

Reduce your intake to a quarter of your regular dose per day or even stop completely for a while. The longer the time between uses, the quicker tolerance breaks down.

To reset a truly high tolerance, at least 2 months’ abstinence should be taken. When dosing after this period of abstinence, be wary of tolerance returning quickly. If it does, then a longer period of abstinence is required to get back to baseline.


When ingesting Kratom, it is important to prevent a buildup of tolerance in the first place. Try and limit dosing to once per day. One large dose is better than several small doses. If you are keen for a recreational experience, try only using two or three times a week. This will give the body some time to adjust brain chemistry back to base level and tolerance can be avoided.

First timers should only use powders and stay away from concentrates as the brain will adapt too quickly to this high dose and tolerance will build rapidly.

Enjoy and be safe.


  Guest Writer  

Written by: Guest Writer
Occasionally we have guest writers contribute to our blog here at Zamnesia. They come from a wide range of backgrounds and experiences, making their knowledge invaluable.

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